The Gujarat Cancer & Research Institute

The department has dedicated medical and pediatric oncology wings, BMT services and clinical trial wing. The department started functioning since 1972 with 100 bedded indoor facility for adult patients and established a separate dedicated 50 bedded pediatric oncology centre in 1992. Department has separate clinical trial wing and Bone Marrow Transplantation facility (Estd. 2000).

Bone Marrow Transplant and Research Unit

Bone Marrow Transplant Unit was established in August 1999, since then a number of transplants have been performed. The centre gets patients from states of Gujarat , Rajasthan, and Madhyapradesh.

The bone marrow transplant centre at GCRI is a 4 Bedded Transplant Centre with 8 step down beds. BMT Unit performs on an average one to two transplants in a month. Total 78 Hematopoietic stem cell transplants have been performed including 56 autologous, 21 allogenic& 1 matched unrelated umbilical cord till date.

The centre mainly focuses on conventional fully (6/6) HLA matched sibling allogenic for Thalassemia Major, Acute leukemia and Aplastic Anemia. Autologous Bone marrow transplantation performed mainly for Lymphomas(Hodgkin's and Non Hodgkin's) and Multiple Myeloma. Positive pressure HEPA filters has helped to achieve a very high success rate in the various types of diseases at our centre. Transplant Related Mortality (TRM) is comparable to any other institute in world.

Average cost of Allogenic Transplant is 5-6 lakh( appx.) and 3-4 lakhs for Autologous transplant .

Allogenic Transplant - 21
AML - 10 Thalassemia – 6 Hurlers – 1 ALL- 1 CML – 2 Aplastic Anemia-1
Autologous Transplant – 56
Multiple Myeloma - 20 HD - 17 NHL - 15 GCT - 2 Ewing 's sarcoma - 1 Neuroblastoma - 1
Umbilical cord blood transplant -1

RESULTS & ANALYSIS:TRANSPLANT OUTCOME at GCRI

AUTOLOGOUS
Disease	No. of pts	CR&Well	Remarks
Hodgkin's dis.	17	12	60-70% survival mean survival > 3 years --80 % pts
NHL	15	06	2 pts completed 8yrs
Multiple Myeloma	20	09	2 pts well after 8 yrs mean survival >3 yrs in 60% of pts
Total	52	27	>50% pts in CR & well

ALLOGENIC
Diagnosis	No. of pts	CR&Well	Remarks
Thalassemia major	06 01	03 01	HLA matched sibling-allo. Unrelated HLA matched umbilical cord Cord blood transplant
Acute myeloid leukemia	10	03	Most of pts transplanted after 2nd remission.
CML-blastic crisis	02	02	1 pt under Rx of chro.liver GVHD
Aplastic anemia	01	01
Total	20	10	50% pts are well

For more information contact:

DR. SANDIP A. SHAH (M.D.) Hemato-oncologist

Incharge Bone Marrow transplant unit.
Gujarat Cancer & Research Institute
Civil Hospital Campus, Ahmedabad. Gujarat.
M :9824041170, 079 -22688182
Email : sandip60@yahoo.com